Why 28 Day Skin is different

28 Day Skin is a revolutionary approach to problem skin.

Acne is a very individual condition because it can have many underlying causes and a treatment that works for some people will not work for others. 28 Day Skin tackles each part of the whole acne formation chain, both internally and externally, rather than focusing on individual parts of the acne forming chain using new technology, effective skincare and nutritional support.

This is why 28 Day Skin differs from existing treatments.

 

 

 

 

 

 

28 Day Skin vs Benzoyl Peroxide

Benzoyl Peroxide is probably the most commonly used acne treatment in the world. When you apply Benzoyl Peroxide to your skin it breaks down and forms oxygen and this floods into your skin pores. To thrive P.Acnes needs a low oxygen environment. The  influx of oxygen into a pore eliminates P.Acnes bacteria, reducing acne, and preventing new pimples from forming. 

 

Benzoyl Peroxide kills bacteria but also has an extremely high number of reported side effects.

 

  • Topical Benzoyl Peroxide has been clinically linked with increasing the sebum excretion rate in patients with acne and sebum oxidation. Sebum oxidation results from sebum reacting with oxygen to form squalene peroxide, a highly comedogenic (pore-blocking) substance and a major contributor to acne formation.  Increased sebum oxidation leads to an increase in blocked pores which leads to an increase in acne. As a consequence people who succeed with Benzoyl Peroxide in the short term often have worse acne returning within weeks or even days. 

  • Benzoyl Peroxide is also reported to cause premature skin ageing. The biochemical triggers that manifest skin ageing, such as wrinkles, altered pigmentation, and loss of skin tone are known as “reactive oxygen species", or more commonly "free radicals", and it is free radicals which are used abundantly in Benzoyl Peroxide to kill bacteria. 

  • Topical antioxidants, such as Vitamin E,  protect skin from the adverse effects of free radicals.  A single application of benzoyl peroxide destroys 93% of the vitamin E associated with the skin. Without vitamin E, skin becomes sensitive and prone to breakouts. Users of Benzoyl Peroxide often report their skin dries out and becomes excessively flaky, red & irritated after a period of use.

  • Benzoyl Peroxide is a known tumour promoter and has been linked to genetic damage in animal tests, however no reports of adverse effects have been documented to date that relate to skin carcinogenesis in humans.

28 Day Skin therapy does not use Benzoyl Peroxide. We believe it's known severe side effects, and the possibility of even greater ones,  significantly outweighs any benefits. Instead we use blue light therapy to eliminate acne-causing bacteria without damaging the surrounding skin, selective topical compounds (like BHA) to help clear pores and a wider more holistic approach to controlling sebum production, balancing bacteria levels and regulating acne forming hormones. The result is the elimination of acne without harsh side effects.

 

 

 

28 Day Skin vs Intense Blue Light devices

Blue light devices are clinically shown to eliminate the acne causing bacteria, P.Acnes. They achieve this because the internal structure of P.Acnes bacteria absorbs light energy at the near ultraviolet (UV) and blue light spectra. Irradiation of P. acnes with blue visible light leads to photoexcitation of the bacteria and bacterial destruction. Destruction of P.Acnes ultimately results in a decrease in inflammation in the pimple and an easing of the symptoms of acne. 

 

However, blue light therapy alone treats one of the symptoms of acne and only eliminates bacteria present at the time of treatment. It will not prevent pore blockage (which provides the ideal conditions for P.Acnes growth) and will not prevent future acne break outs. Stopping blue light treatment provides no ongoing therapy and acne will continue to return.

28 Day Skin uses high intensity blue light to reduce the number of P.Acnes to alleviate acne symptoms. It does this within a process that decreases the growth of further P.Acnes  (by unblocking pores that provide the environment that P.Acnes thrives in). In addition 28 Day Skin affects the acne forming process by controlling sebum production through topical ingredients and nutrients (which help balance hormone levels). This reduces the likelihood of future break outs.

 

28 Day Skin vs Antibiotics (Minocycline, Tetracycline)

Minocycline is an antibiotic commonly prescribed to treat infections, such as urinary tract infections, acne and chlamydia. It has a large number of reported side effects ranging from the staining the teeth brown, grey, black, or blue, especially along the gum line to autoimmune disorders such as drug related lupus and auto-immune hepatitis. Studies have linked the use of Minocycline to increased sebaceous excretion, even after the end of treatment, which can result in worse acne than before (1). Tetracycline is an antibiotic used to treat a number of infections including, in addition to acne, cholera, brucellosis, plague, malaria, and syphilis. As a broad spectrum antibiotic it is very effective at destroying acne causing bacteria; however like Minocycline the drug has a large number of reported side effects.

Both Minocycline  and Tetracycline used to be very popular for treating acne however, acne that is caused by antibiotic resistant bacteria is a growing problem in many countries and treatment using antibiotics caused by bacteria (primarily Propionibacterium acnes) that are resistant to these antibiotics is less effective. (2) 

28 Day Skin uses high intensity blue light to reduce the number of P.acnes. This method kills the bacteria by photoexcitation of the bacteria, a process by which antibacterial resistance can not occur and without the side effects of antibiotic treatment. This allows the 28 Day Skin to be used as a safe and effective treatment against antibiotic resistant bacteria and without contributing to further antibiotic resistance.

 

28 Day Skin vs Topical Tretinoin (Retin-A and Avita creams applied directly to the skin)

Tretinoin, also known as all-trans retinoic acid (ATRA) is the active ingredient in topical Retin-A and Avita.  Tretinoin targets the 'sebum plug' part of the acne formation process by stimulating the growth of the skin to open pores and allow their contents to drain. It also desensitises skin cells to the immune system, reversing their sensitivity caused by the toxic bacterial secretions.  There are many potential side effects including skin irritation, peeling, redness, swelling, and blistering (3) and users are advised not to use any cream or lotion that has a strong drying effect, contains alcohol, astringents, spices, lime, sulfur, resorcinol, or aspirin, as these may interact with Tretinoin or exacerbate its side effects.

 

Similar to our approach on Benzoyl Peroxide, 28 Day Skin therapy does not use Tretinoin. While we agree it is a useful tool against severe acne we believe its known severe side effects significantly outweighs any benefits for mild to moderate acne symptoms. Instead we use selective topical compounds (like BHA) to help clear pores, blue light therapy to eliminate acne causing bacteria without damaging the surrounding skin and a wider more holistic approach to controlling sebum production, balancing bacteria levels and regulating acne forming hormones. The result is the elimination of acne without harsh side effects.

 

 

28 Day Skin vs Isotretinoin 

Isotretinoin, also known as Claravis, Accutane and Roaccutane, is an effective prescription drug which combats acne by reducing the production of sebum, reduces cell shedding and the stickiness of cells in the follicles.  Treatment generally takes between 16 and 24 weeks and has a very high rate of success (4). Isotretinoin has many potential side effects, some serious including 44 suspected suicides (5), since it was registered in 1983. While Isotretinoin, used to treat acne vulgaris, has not been clinically demonstrated (6) to be associated with depression or suicide, the possibility of a relatively rare idiosyncratic adverse effect remains. In addition, recent clinical data has suggested that Isotretinoin may have a lower long-term cure rate than was initially thought, and the relapse rate may be higher.(6)(7)(8)

We believe it's known severe side effects  significantly outweigh any benefits for mild to moderate acne symptoms. 28 Day Skin therapy does not use Isotretinoin but instead focuses on a wider more holistic approach to the treatment of mild to moderate acne.

(1) Bodokh I, Jacomet Y, Lacour JP, Ortonne JP (July 1997). "Minocycline induces an increase in the number of excreting pilosebaceous follicles in acne vulgaris. A randomised study". Acta Derm Venereol. 77(4): 255–9. doi:10.2340/0001555577255259PMID 9228213.

(2) Ross; et al. (2003). "Antibiotic-resistant acne: lessons from Europe". British Journal of Dermatology. 148 (3): 467–78. doi:10.1046/j.1365-2133.2003.05067.xPMID 12653738.

(3) British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 627, 821–822. ISBN 9780857111562.

(4) Parker Magin, . Isotretinoin, depression and suicide: a review of the evidence (2005) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463189/

(5) Controversial acne drug blamed for a number of suicides. The Telegraph 04 Jul 2013. https://www.telegraph.co.uk/news/health/10160484/Controversial-acne-drug-blamed-for-a-number-of-suicides.html

(6) Alison Layton (2009) The use of isotretinoin in acne. Dermatoendocrinol. 2009 May-Jun; 1(3): 162–169. PMID: 20436884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835909/

(7) Layton et al. Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment. Br J Dermatol. 1993 Sep;129(3):292-6.
https://www.ncbi.nlm.nih.gov/pubmed/8286227

(8) Azoulay et al. Isotretinoin therapy and the incidence of acne relapse: a nested case-control study. Br J Dermatol. 2007 Dec;157(6):1240-8. Epub 2007 Oct 26. https://www.ncbi.nlm.nih.gov/pubmed/17970803/

(9) Strauss JS et a. Isotretinoin therapy for acne: results of a multicenter dose-response study. J Am Acad Dermatol. 1984 Mar;10(3):490-6.https://www.ncbi.nlm.nih.gov/pubmed/6233335/

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