28 Day Skin One Pill
The symptoms of acne and problem skin are seen on the surface but the source of problem skin is almost always found within. Two major drivers in the acne formation chain are hormones and inflammation. Hormones which are out of balance can cause increased sebum production and skin cell growth. Inflammation can start the acne formation process and an individual’s immune system function determines how acne develops. If our body does not have the necessary building blocks to help regulate hormones and inflammation response, break outs will always continue to reoccur no matter what treatments we use on the outside.
Clinical evidence has shown that acne sufferers are often deficient in certain key nutrients. By maintaining a balanced diet and supplementing with 28 Day Skin's One Pill in combination with 28 Day Skin Therapy treatments the severity of acne can be reduced or eliminated altogether. One Pill is suitable for Vegetarians.
How it works
The 28 Day Skin One Pill contains zinc, vitamin D, green tea and probiotics in clinically significant doses.
Zinc: Zinc Gluconate (12.9%). 387.6mg providing 50mg elemental zinc per tablet
Zinc facilitates apoptosis, or programmed cell death, which is a natural part of your skin renewing itself. If apoptosis is delayed, as in the case of zinc deficiency, skin cells stick together instead of dying and sloughing off like they should, which leads to clogged pores. Zinc gluconate has been shown to decrease inflammatory acne lesions by 49.8% over 3 months by reducing or reversing chemical changes in the skin caused by acne (1). It is believed Zinc fights acne by carrying vitamin A to your skin and by regulating your body’s hormonal balance. Clinical data shows that people who suffer from acne are generally zinc deficient. On average people with acne have 24% lower zinc levels than those without acne. (2)
Vitamin D: 1,000 IU vitamin D3
Vitamin D exerts anti-inflammatory and antimicrobial properties by increasing antimicrobial peptides, which are naturally occurring antibiotics that help fend off bacteria. Studies have identified vitamin D receptors located in sebocytes, the cells lining sebaceous glands, suggesting vitamin D may play a role in the pathophysiology of acne. A clinical study found that low vitamin D status was associated with the onset and severity of acne. The study also discovered that 1,000 IU vitamin D3 supplementation decreased inflammatory lesions by 34.6% after 8 weeks (3).
Green Tea: Green Tea (20:1) 42.5mg Providing 850mg per Capsule
Green tea has been clinically shown to help protect against acne-causing inflammatory damage. The antioxidants in Green tea are able to enter the skin and affect the molecular mechanisms behind acne. Green tea reduces the sensitivity of acne-prone skin to androgen hormones by blocking androgen receptors in the skin. It is also strongly anti-inflammatory and can dampen the inflammatory response to acne-causing bacteria and protect the skin from external sources of inflammation. In a clinical study, patients witnessed a 20% reduction in skin reddening after ingesting a daily supplement of 450 mg green tea extract and 50 mg vitamin C. (4)
Probiotics: Lactobacillus acidophilus 10 billion colony-forming units 50 mg providing 5 Billion units.
A strain of friendly lactic bacteria called Lactobacillus Acidophilus which boosts the existing population found in a healthy gut, and offers full-spectrum support of the upper and lower bowel. 10 billion friendly bacteria per capsule - equivalent to 20 pots of probiotic yoghurt, but without the added sugar, dairy and fat. Probiotics help maintain a healthy digestive system by augmenting the body's natural intestinal microbial population beyond the amount already existing to help inhibit pathogens. Probiotics have been shown to reduce levels of insulin-like growth factor 1 (IGF-1), a hormone-like substance that drives acne. Excessive production of IGF-1 increases inflammation as well as sebum production, the key causes of acne.(5) A study (2010) showed decreases in acne inflammatory lesion count by 38.6%, total lesion count by 23.1%, and acne grade by 20.3% compared with a placebo over a twelve-week period when the patients consumed Lactobacillus-fermented milk.(6)
(1) Multicenter Randomized Comparative Double-Blind Controlled Clinical Trial of the Safety and Efficacy of Zinc Gluconate versus Minocycline Hydrochloride in the Treatment of Inflammatory Acne vulgarisDermatology 2001;203:135-140. Dreno et al.
(2) Ozuguz et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2013 Jul 5 Cutaneous and Ocular Toxicology Volume 33, 2014 - Issue 2
(3) Seul-Ki Lim et. Al. Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial. PLoS One, 2016.
(4) Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. British Journal of Nutrition Volume 110, Issue 5 September 2013, pp. 891-900Rhodes et al.
(5) Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013;17(2):114-22. Jung GW, Tse JE, Guiha I, Rao J.(6) Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010;26(9):902-9. Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y.(7) A. Efficacy of regulators of the intestinal bacterial flora in the therapy of acne vulgaris. Clin Ter. 1987;122(5):339-43. Marchetti F, Capizzi R, Tulli(8) Lactobacillus for the control of acne. J Med Soc New Jersey. 1961;59:52–53. Siver RH.